Role of Exposome in Uncontrolled Asthma: An Update

Abstract

Asthma is known to be one of the  patient  complaint and is caused by  multi  factors including genetics, diet, environmental exposures, respiratory infections, and other factors. Studies show that around 1 in 10 children are set up to be affected this condition worldwide, which is characterized by ongoing symptoms  similar as  patient cough,  briefness of breath,  gasping. It's a  miscellaneous condition that varies from person to person grounded on factors like age of onset, treatment response, clinical signs, environmental factors, and overall progression. Exposomes  synopsize the aggregation of internal and external sources of chemical substances,  natural agents, and cerebral factors to which an  existent is exposed over a lifetime. Internal exposomes involve factors like oxidative stress, inflammation, disordered metabolism and hormonal changes. Microbial exposure,  unresistant smoking, air pollution and socioeconomic conditions are part of external exposomes. Asthma affects about 339 million  individuals, out of which 33 are children under the age of 14, 27 are grown-ups who developed asthma in nonage, 40 are  individuals diagnosed during adulthood. This review aims to interpret the environmental factors that leads to DNA damage in children suffering from  uncontrolled asthma. It points out how the environmental exposures including air pollution,  habitat , allergens and nutrition- related factors can increase oxidative stress and genomic stability, making asthma more  habitual and  inadequately controlled in children . Recent studies shown that the  disabled regulation of DNA damage signaling pathways in the lungs can  impact the development.

Keywords- DNA damage , Exposomes,