ROLE OF MAST CELLS IN ORAL LEUKOPLAKIA, ORAL SUBMUCOUS FIBROSIS & ORAL SQUAMOUS CELL CARCINOMA-A QUANTITATIVE STUDY

Authors

  • Dr. Jahnobi Dutta

Abstract

Mast cells are immune cells that accumulate in the tumors and their microenvironment during disease progression. Mast cells are armed with a wide array of receptors that sense environment modifications and, upon stimulation they are able to secrete several biologically active factors involved in the modulation of tumor growth. For example, mast cells are able to secrete pro-angiogenic and growth factors but also pro- and anti-inflammatory mediators. Here we review that mast cells has a role in pathogenic surveillance, impact on biological factors and also act as gatekeepers in the microvasculature in the oral cavity. Moreover, the degrees of mast cell count in OSMF, Oral leukoplakia and Oral Squamous Cell Carcinoma. The purpose of the current study was to examine the histological progression from normal oral tissues through premalignant condition like OSMF, premalignant lesion like leukoplakia to OSCC.

Keywords: Mast cells, Oral Submucous Fibrosis, Oral Leukoplakia, Oral Squamous Cell Carcinoma

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Published

2019-04-28

How to Cite

Dr. Jahnobi Dutta. (2019). ROLE OF MAST CELLS IN ORAL LEUKOPLAKIA, ORAL SUBMUCOUS FIBROSIS & ORAL SQUAMOUS CELL CARCINOMA-A QUANTITATIVE STUDY. International Journal of Medical Science And Diagnosis Research, 3(4). Retrieved from https://ijmsdr.com/index.php/ijmsdr/article/view/357

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