CLINICOPATHOLOGICAL CORRELATIONS OF BIOPSY PROVEN RENAL DISEASE IN MINIA UNIVERSITY HOSPITAL
Abstract
bjective: Glomerular disease (GD) is one of the most common forms of renal diseases and can have many different clinical presentations. It can present as nephrotic syndrome (NS), nephritic syndrome, rapidly progressive renal failure (RPRF), acute kidney injury (AKI), chronic kidney disease, macroscopic hematuria (MH), recurrent disease in the post-transplant kidney, as well as isolated proteinuria or hematuria. In any case, a kidney biopsy is needed for the correct characterization of various types of GD.
Aim of the work: To comprehensive information about the demographics, clinical presentation and pattern of kidney diseases diagnosed by renal biopsy in Minia Univrsity Hospital.
Methods: The study included 104 patients admitted to renal unit at El-Minia university hospital with mean ages 31.65±13.77 years. These patients selected from January 2014 to Augest 2016.This study included 40 patients retospectively from January 2014 to March 2015 and continued prospectively for 64 patients from April 2015 to Augest 2016.
Results: All renal biopsy specimens obtained were prepared as the standard protocol analysis included light microscopy (LM) . In Our Study, the most common renal diseases was Lupus Nephritis (27.9%), followed by membranoproliferative glomerulonephritis (15.4%) , focal segmental glomerulosclerosis (13.5%),tubulointerstitial nephritis (11.5%), amyloidosis (7.7%) , crescentic glomerulonephritis (5.8%), thrombotic microangiopathy (4.8%), vascular nephropathies (3.8%), minimal change disease (3.8%), membranous nephropathy (2.9%), postinfectious glomerulonephritis (1.9%) and diabetic nephropathy (1%).
Conclusion: The most often diagnosed glomerular disease in our study was lupus nephritis which was the main cause of secondary kidney disease followed by membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis.
Keywords: Clinicopathological, biopsy, renal disease, Glomerular
