ABO BLOOD GROUPS AND RH FACTOR ASSOCIATION WITH ORAL SUBMUCOUS FIBROSIS: A CLINICAL SHORT STUDY IN JODHPUR POPULATION.

Abstract

BACKGROUND: The ABO blood group antigens are present on the surface of red blood cells and various epithelial cells. As majority of human cancers are epithelial in origin, changes in blood group constituents an important aspect of human precancerous conditions .The aim of the study is to establish clinical usefulness of ABO blood group as predisposing factor in early diagnosis and management of patients with Oral submucous Fibrosis.
Materials and Methods: The study sample consists of 130 control and 130 Oral submucous Fibrosis Patients. All samples were subjected to blood group testing and histo-pathologic examination. Passi D et al (2017) classification system has been used for grading of Oral Sub mucous Fibrosis.
Result: Probability of developing Grade I and Grade II oral submucous fibrosis is high in A+ve blood group people associated with habit of consuming arecanut, gutkha and other tobacco containing products. Likewise B+ve blood group people with habit of consuming tobacco products are more prone to develop Grade III and O+ve blood group are prone for developing Grade IV OSMF
Conclusion: Blood group with Rh type should include the other risk factor of the disease to get the knowledge of patient’s risk. Further studies need to be done on large scale with inclusion of Hb % value to elucidate the relationship with ABO blood group.
Keywords: ABO Blood Group, Oral submucous Fibrosis (OSMF), antigen (Ag)