PREVALENCE OF HUMAN PAPILLOMA VIRUS IN HEAD AND NECK CARCINOMA

Abstract

Background: Growing evidence suggests a role for human papillomavirus (HPV) in oral cancer; however its involvement is still controversial. This study evaluates the frequency of HPV DNA in oral cancer cases.
Aim: to evaluate the frequency of HPV DNA in oral cancer cases and report association, if any.
Materials and Methods: We performed a hospital-based, case–control study of 100 patients with newly diagnosed oropharyngeal cancer and 200 control patients without cancer to evaluate associations between HPV infection and oropharyngeal cancer. Results were statistically analyzed.
Results: A high lifetime number of vaginal-sex partners were associated with oropharyngeal cancer as were a high lifetime number of oral-sex partners. The degree of association increased with the number of vaginal-sex and oral-sex partners. Oropharyngeal cancer was significantly associated with oral HPV type 16 infection
Conclusion: Oral HPV infection is strongly associated with oropharyngeal cancer among subjects with or without the established risk factors of tobacco and alcohol use.
Keywords: carcinoma, mortality, oropharyngeal, vaccine, preventive