ROLE OF CYSTATIN C IN DIABETIC NEPHROPATHY

Abstract

Background: Diabetic Nephropathy is consider as one of the major micro-vascular problems of diabetes mellitus and has become the most general single factor of end stage of kidney disease. It is defined traditionally by kidney morphological and modification like: glomerular hyper filtration, glomerular and kidney hypertrophy, increased urinary albumin excretion (> 300 mg/24 hours), increased GBM (Glomerular Basement Membrane) thickness and mesangial expansion and also accumulation of extracellular proteins comprising laminin, collagens and fibronectin worldwide. Cystatin C is a low molecular weight protein and freely filtrates by kidney. Cystatin c doesn't affected via age, sex, weight and diet.

Objective of the study: The role of cystatin c level in early detection of DN.

Materials and methods: The investigation was conducted on 100 DN subjects of both sex and aged 20 or more and 100 age and sex matched healthy control subjects. Cystatin C of each subject was measured in untimed serum specimens.

Results: the present investigation shows that the cystatin c in serum was elevated significantly in DN individuals as compared to controls.

Conclusion: This study concluded that the cystatin C could be better serum marker for early recognition of DN. 

Keywords: Diabetic nephropathy (DN), Cystatin C, Kidney disease